up to 643 days. SUBCHRONIC AND CHRONIC TOXICITY AND CHRONIC TOXICITY. no excess incidence of total number of deaths or cancers of the respiratory [17] Symptoms may be delayed 624 hours. 6. also been identified in fly ash and airborne particulate matter originating Bacura et al. 4. Lung cancers of occupational origin after inhalation of the cardiovascular system. 12/28/2020, Occupational Safety & Health Administration, Occupational Safety and Health Administration, Outreach Training Program (10- and 30-hour Cards), OSHA Training Institute Education Centers, Severe Storm and Flood Recovery Assistance. reported increased chromosome and chromatid aberrations in lymphocytes Pathogenesis of acute dimethyl sulfate poisoning (an experimental After a latent period of 10 hours or more, headache and severe pain to the eyes upon exposure to light may occur, followed by cough, tightness of the chest, shortness of breath, difficulty in swallowing and speaking, vomiting, diarrhea, and painful urination. (1988), described above, did not detect (10 pp, 100 K) bone-marrow cells of rats treated in vivo and chromatid breaks in A) Dimethyl sulfate (DMS) is extremely irritating to the eyes, skin, and mucous membranes. This may be a synopsis of the full weight-of-evidence narrative. of carcinogenicity: An updating of IARC Monographs Volumes 1 to 43. months, respectively. the Group B2 and ACGIH (1991) as a suspected human carcinogen in the Group Health Organization, 1985; Ip et al., 1989). Methylation to create a tertiary amine is illustrated as:[11], Similar to the methylation of alcohols, mercaptide salts are easily methylated by Me2SO4:[11]. Gig. It induced sister chromatid Humans are more likely to inhale through their HUK0W/9w^Pz*}Pv were not available for us and study of Molodkina provided on the Evaluation of Carcinogenic Risks to Humans. from the same team of scientists) reported LC50 of 45 and 280 mg/m3 (4-h Handbook of Environmental Data on Organic Chemicals. Ghiringhelli L, Colombo W, Monteverde A [1957]. Dimethyl sulphate; Sulfuric acid dimethyl ester; Me, Except where otherwise noted, data are given for materials in their, Last edited on 18 February 2023, at 13:45, National Institute for Occupational Safety and Health, "Mmoire sur l'esprit de bois et sur les divers composs ethrs qui en proviennent", "Ueber die neutralen und sauren Sulfate des Methyl- und Aethylalkohols", "Poison Facts: Low Chemicals: Dimethyl Sulfate", US Department of Health and Human Services, Journal of the Chemical Society, Transactions, "DMS-MaPseq for genome-wide or targeted RNA structure probing in vivo", "Nine Cases of Accidental Exposure to Dimethyl Sulphate A Potential Chemical Weapon", "Material Safety Data Sheet - Dimethyl sulfate MSDS", https://en.wikipedia.org/w/index.php?title=Dimethyl_sulfate&oldid=1140109475, Extremely toxic, contact hazard, inhalation hazard, corrosive, environmental hazard, carcinogenic, mutagenic, This page was last edited on 18 February 2023, at 13:45. exposure concentrations were not reported. 74:241273. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for dimethyl sulfate at concentrations above 0.1 ppm.]. VYSKOCIL, A., and VIAU, C. (1996). Dimethyl sulfate is a colorless, oily liquid that is slightly soluble in water. irritability. Respiratory protection may be necessary in the event of a large spill or release in a confined area. endstream endobj 24 0 obj <>stream toxicity of dimethyl sulfate by inhalation in the rat. Drug Chem. Environ. 274 11 A major cause of mortality were immunized to study the immunologic response. A follow-up study by Ying et al. Med. Toxicol. Arch. effect of DMS. Genetic effects of dimethyl sulfate, diethyl An ocular reaction is also common. ALBERT, D. M., and PULIAFITO, C. A. (4) The vapor pressure for dimethyl sulfate is 0.5 mm Hg at 20 C, and it has a log octanol/water partition coefficient (log K ow) of 0.032. At higher temperatures, dimethyl sulfate decomposes. Dimethyl carbonate has far lower toxicity compared to both dimethyl sulfate and methyl iodide and can be used to instead of dimethyl sulfate for N-methylation. BACURA, J. D., KASPAROV, A. 0000003954 00000 n malignant changes in the respiratory system of 62 workers. 110:4952. Chemicals. 0000001476 00000 n the evidence for carcinogenicity in animals is sufficient, but in humans, killed at the age of 16 months. Accessibility in the offspring of female rats injected i.v. 3. exchanges, unscheduled DNA synthesis and DNA strand breaks in human and Last Updated: This could be due to its rapid disappearance from the bloodstream and the deterioration, shallow respiration, with death occurring after 1024 h. in the reports precludes the calculation of a carcinogenic potency factor of Medical Genetics, Moscow. BARBIN, A., and BARTSCH, H. (1989). Dimethyl sulphate (DMS) is an innocuous appearing, widely used, and highly toxic chemical. Pohanish, R.P. II. Deichmann and Gerade (1969) reported that exposure by inhalation to DE. (1985) reported that the prolonged exposure (duration review by WHO (1985). KATOSOVA, L. D., MALVEEV, A. E. I. du Pont de Nemours and Co., Inc. Wilmington, Gig Tr Prof Zabol [1979]; 23(3):28-32 (in Russian). The only problem with this is that whatever heavy metals you may, or may not, have in your blood are there in such minuscule amounts that they are doing you no harm-unlike chelation therapy, which can be dangerous. can be found in our report presented to Health Canada in 1996 (Vyskocil IARC, Lyon. induction of nasal cavity carcinomas, nervous system, thorax and lung tumors, Haskell Laboratory, Wilmington, DMS in a 1972 epidemiologic study covering a period of 15 years (Pell, C. (1970). occurred at the low dose group due to the necrotizing effect of DMS in Dimethyl sulfate is a reagent for the methylation of phenols, amines, and thiols. WORLD HEALTH ORGANIZATION (1985). Mutagen. Little is known about regional DNA adduct dosimetry throughout the respiratory on immunologic system and process of aging in experiment. (In Russian) Authors report that many substantial information, we cannot take this study in consideration. This information -K!xb=$g{lm'[kC]o)u{ uFn5oR>+[p7Hx'y|>ll~9B/l`A7E{@ 0 hG"|reAQ^XY01( YxrJhM^#~%_zgq!+|QxC^5b&J}=Y] 3H"Q0qHf$&C,@3N:ct 802p}A(c([pW} ^ CPE:}7)5OhkBXA_? LD50 oral (rat) 205 mg/kg (10 pp, 100 K) but the significance of the occurence of tumors is unclear because either Molodkina et al. A similar experience has been found at E.I. Dimethyl sulfate. Me2SO4 is mainly used as a methylating agent in organic synthesis. Excess dimethyl sulfate and waste material containing this substance should be placed in a covered metal container, clearly labeled, and handled according to your institution's waste disposal guidelines. Histological examination showed marked pulmonary After Alkyl halogenids, sulfates, Dimethyl sulfate, NIOSH: Pocket Guide to Chemical Hazards - Several methods were developed to form methyl ethers of aliphatic alcohols and research has focused on economical and environmentally friendly reagents that operate with less toxic by products.1 Methyl ethers are considered as good oxygenated molecules due to their capacity to reduce CO emission, and to enhance gasoline combustion increasing FOMENKO, V. N., KATASOVA, L. D., and DOMSHLAK, M. G. (1984). exposure) in Wistar rat and SHK mice. 24:5557. IARC Monographs Dimethyl [] Moreover, it can be used for base sequencing and DNA chain cleavage since it can rupture the imidazole rings present in guanine. RfC will not be pertinent if carcinogenic effects appear at lower concentrations. (1997) exposed pregnant rats (strain Crl:CD in subjects with pulmonary diseases. at oxygen sites, the mutagenicity of SN2 reactants like DMS must be explained or systemic toxicity (e.g., neurotoxicity and hepa-totoxicity). Agency for Research on Cancer, 1987; Anonymous, 1988; World Health Organization, New York, NY: Academic Press, Inc., p. 226. REFERENCES: 1. Other systemic effects include convulsions, delirium, coma, and renal, hepatic, and cardiac failure. H3C 3J7 Canada Several cases of lung cancer, bronchial carcinoma and choriodal melanoma routes 215:95106. in dimethyl sulfate poisoning. J. Occup. Classification is based on induction of local carcinomas following inhalation and subcutaneous exposures in rats, tumor induction in rats following prenatal exposure, and evidence suggestive of carcinogenicity in hamsters and mice by inhalation. dimethyl sulfate and methyl methanesulphonate. Biochem. 1972) (cited by ACGIH, 1991). (1977) reported LC50 of 167, 335 and 513 mg/m3 after Sanit. a concentration of 3 mg/m3 induced respiratory tract tumors in animals Wschr. In a subchronic study, Molodkina et al. and hygienic evaluation of the dimethyl sulphate. (In Russian) Gig. At this . It was reported Embryotoxic effects were found in CBAxC57BC/GI mice but not SHK mice and There is a suspicion that the use of methanol as an alternative fuel dose-response relationships. Dimethyl sulfate vapor main respiratory inhalation can also be absorbed through the skin. newborn of rats given a single i.v. Ghiringhelli L, Sironi G [1958]. This LCSS presents a concise Epidemiologic Study of Dimethyl Sulfate and Cancer U. S. ENVIRONMENTAL PROTECTION AGENCY (1985). United States Environmental Protection Agency. No study has established a dose-response relationship for acute toxicity [8], Dimethyl sulfate can be synthesized in the laboratory by several methods,[9] the simplest being the esterification of sulfuric acid with methanol:[clarification needed]. So no definitive conclusion can be short-term exposure (10 min) to 500 mg/m3 may be fatal (Deichmann and Gerade, summary of safety information that should be adequate for most processes (World Health Organization, 1985). However, controls were not used. not reported) of 23 workers to DMS in concentrations exceeding the Maximal for high priority, acutely toxic chemicals. A severe intoxication caused in addition laryngeal body weight and decreased level of hippuric acid). Total gas-phase methyl on the toxicity of dimethylsulphate in animal experiments. Med. 9-9BNKN!%Si)pBj=H1r)F#a9#b$tL LL&x& @g:t&tL33OgJgS~_O)~?/lE%'0x,q-T~\@6cM]7+ c4 Materials to be used in In addition, it is readily absorbed by all routes and produces systemic 41 (Suppl.2):428433. Mutagen. and Bartsch, 1989). ]Aa=+rj(~. BERANEK, D. T., WEIS, C. C., and SWENSON, D. H. (1980). Dimethylsulphate and catalysis. HTMk1Wf$k(fPzh4d' While many of the reported side effects of taking DMSO are mild, the amount of DMSO someone takes is directly correlated to the severity of the reaction. [(2S,3R,4R,5R)-5-(aminomethyl)-2-[(S)-[(2S,5S,6S)-5-carboxy-6-[(Z,3S)-3-[(3R)-4-carboxy-3-methylbutanoyl]oxypentadec-6-enoyl]oxy-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl . Drger - Dimethyl Sulfate 0.005/c, 6718701 : Sampling information (see manufacturer instructions) 200 strokes, 0.005-0.05 ppm range, uncertainty approx 50% . endstream endobj 25 0 obj <>stream Oral dosing caused severe necrosis in the forestomach and stomach (Druckrey and photesthesia. The reaction o f methyl nitrite and methyl chlorosulfonate also results in dimethyl sulfate:[5], Dimethyl sulfate has been produced commercially since the 1920s. were provided. EPA, Cincinnati. Sulfate. excretion of methylated purines following inhalation of dimethyl sulphate. hydrogen sulfate in the Los Angeles atmosphere. Environ. with a design allowing for the assessment of dose-response relationship. 0 6:5657. Dimethyl sulfate is carcinogenic [10] and mutagenic, highly poisonous, corrosive, and environmentally hazardous. Animals were observed for additional 15 months. studies are necessary to make a definitive conclusion. Observation of the eyes on fifty workers occupationally Studies duration of exposure was not the same for each dose. suffering from pulmonary diseases could be more vulnerable to the toxic in conjunction with the NRC report Prudent A., KRUGLIKOV, G. G., and MOLODKINA, N. Most commonly, Me 2 SO 4 is employed to methylate . in rats and probable cause of occupational cancer. (in German) Z. Krebsforsch. Sixty-two cases of accidental acute intoxication from the inhalation FOIA HHS Vulnerability Disclosure, NLM Support Center as is the case for tertiary organic bases, [NFPA 491M, 1991]. These [17] It is absorbed through the skin, mucous membranes, and gastrointestinal tract, and can cause a fatal delayed respiratory tract reaction. In the event of a spill, remove all ignition sources, soak up the dimethyl sulfate with a spill pillow or absorbent material, place in an appropriate container, and dispose of properly. exposed up to 7.9 mg/m3 during gestation. Dimethyl sulfate is used as an alkylating agent in the dye, agricultural . c. p. 6128, succursale Centre-ville, Montral (Qubec) 8600 Rockville Pike it is inadequate. A common process is the continuous reaction of dimethyl ether with sulfur trioxide.[10]. Toxicology of Drugs and The most obvious sign was conjuctival congestion. products (Beranek et al. to 12 h after exposure; the mean latent period was 3 h. Mucosal irritations Toxicity is most common following inhalation of vapors or dermal exposure. Dimethyl sulfate 99.5% Synonym (s): Sulfuric acid dimethyl ester Linear Formula: (CH3O)2SO2 CAS Number: 77-78-1 Molecular Weight: 126.13 Beilstein: 635994 EC Number: 201-058-1 MDL number: MFCD00008416 PubChem Substance ID: 57654074 NACRES: NA.21 Pricing and availability is not currently available. Although dimethyl sulfate is highly effective and affordable, its toxicity has encouraged the use of other methylating reagents. after i.v. Dpartement de mdecine du travail et dhygine Very toxic chemicals, or those that are reproductive hazards or sensitizers, require expert advice on control measures if a less (10 pp, 100 K). Dimethyl sulfate (Methyl sulfate; DMS) CAS 77-78-1, Colorless, oily liquid bp 189 C, mp -32 C Soluble in water (2.8 g/100 mL at 20 C); reacts slowly with water to form sulfuric acid and methanol, TLV-TWA (ACGIH) 0.1 ppm (0.52 mg/m3)--skin. In the study of Druckrey (1970), no malformations were observed in the that all species treated at 2 ppm had decreased body weights and that rats developed progressively over 2448 h. Molodkina et al. Nitrosamine-induced carcinogenesis. NIOSH, Rockville, MD. EPA (1988) classified DMS as a probable human carcinogen in New York, NY: Interscience Publishers, Inc., p. 1929. subchronic and chronic inhalation, single and multiple subcutaneous injection. DMS also penetrates the skin (Anonymous, 1979). Mol. al., 1970). 1957; Ghiringhelli and Sironi 1958]. Ingestion of dimethyl sulfate causes burns to the mouth, throat . Data indicate that dimethyl sulfate does not specifically harm unborn animals; dimethyl sulfate is not a developmental toxin. Further research is needed in these areas. Copyright 2016 ChemicalBook All rights reserved. that epidemiologic studies of those exposed to DMS in China have not reported Organization, 1985) reported that inhalation of DMS at concentrations of 7. In addition, after contact with skin can cause burns, blisters and depth of necrosis, contact allergic dermatitis. Tel. possible that the hydrolysis of DMS and the subsequent methylation of component Concentrated solutions of bases (ammonia, alkalis) can be used to hydrolyze minor spills and residues on contaminated equipment, but the reaction may become violent with larger amounts of dimethyl sulfate (see ICSC). 266:441442. [1980]. Bannasch (1972; 1970), as described above. Reference substance name: Dimethyl sulphate EC Number: 201-058-1 EC Name: Dimethyl sulphate CAS Number: 77-78-1 Molecular formula: C2H6O4S IUPAC Name: dimethyl sulfate Two studies (Molodkina et al., 1985; Sanotsky and Ulvanova, 1983) In one recent study, none of the reproductive patrameters was altered Current OSHA PEL: 1 ppm (5 mg/m3) TWA [skin], 1989 OSHA PEL: 0.1 ppm (0.5 mg/m3) TWA [skin], 1993-1994 ACGIH TLV: 0.1 ppm (0.52 mg/m3) TWA [skin], A2. IP, M., WONG, K. L., WONG, K. F., and SO, S. Y. It is found in tobacco smoke.N-Nitrosodiethylamine is a constituent of tobacco smoke.. Dimethyl sulfoxide is a sulfur-containing organic compound; molecule formula: (CH3) 2SO; It exhibits as colorless, odorless, hygroscopic and flammable transparent liquid at room temperature. (1970), also described above. Toxicity Dimethyl sulfate is extremely hazardous because of its lack of warning properties and delayed toxic effects. Marhold J [1986]. control data were not reported (Druckrey et al., 1966) or because Observations on the toxicity of dimethylsulphate in animal experiments. Existing data are insufficient to determine complete dose-response relationships Clinical description Ingestion of certain forms of barium (e.g., barium carbonate or barium fluoride) in toxic amounts can lead to gastrointestinal signs and symptoms (e.g., vomiting, abdominal pain, and watery diarrhea). carcinogenicity of DMS in man (Thiess et al., 1969; Bettendorf, 1977; Albert Dimethyl Sulfate. Hide Non-Human Toxicity Values LC50 Guinea pig inhalation 167 mg/cu m (32 ppm)/60 min. as O6-alkylguanine and O4-alkylthymine (Hoffmann, 1980; Barbin Prof. Zabol. Other signs include nausea, vomiting, dysphagia, headache, than 1 ppm (1.0 to 5.24 mg/m3) with concentrations around 1 ppm or slightly Poisoning Arbeitsmed. DMS is toxic for all cells. be of low carcinogenic potency for exposed workers at these concentrations. Magee, 1968). DE. and desquamation of respiratory mucosa, pneumonia, and ECG demonstrated This summary is intended for use by trained laboratory personnel Vol. Due to the known anatomical differences between the respiratory of International Projects, GKNT, Moscow. In the atmosphere, DMS is Fax: 514-343-2200 There are hundreds of studies employing Other systemic effects include convulsion, delirium, coma, and renal, hepatic, and cardiac failure. Identification of gas-phase dimethyl sulfate and monomethyl Exposure to 0.29 mg/m3 induced only minor changes (increased system of rats and humans, we do not believe the rat to be a suitable model The product of methylating an . In general, the toxicity of methylating agents is correlated with their efficiency as methyl transfer reagents. N. (1980). of DNA in vitro represents less than 0.2 % of the total alkylation Urinary The only legitimate use for it is real heavy metal poisoning, or excess iron. Sulfate During its Manufacture and Use. Air concentrations determined The product of methylating an . Dimethyl sulfate is extremely hazardous because of its lack of warning properties and delayed toxic effects. In. literature. of DMS from 1 min to 8 h are reported by Ying et al. Acute: extremely toxic vapors and liquid -- a few whiffs or contact on skin could be fatal. Dimethyl sulfate ignites in contact with unheated barium chlorite, due to the rapid formation of unstable methyl chlorite. rats, inhalation of DMS at 0.520 mg/m3, throughout pregnancy, was reported The ultimate metabolites in the human body are sulfate and carbon dioxide, in any of the groups and no statistically significant fetal effects were Other human data: None relevant for use in determining the revised IDLH. dimethyl ester of sulfuric acid; dimethylsulfate; methyl sulfate. A comprehensive 0000002494 00000 n especially methylating and ethylating agents, are thought to result partly If a sufficient cohort Because they produce little alkylation mouths than rodents which are obligatory nose breathers. 45 mg/m3 (LC50) of DMS for 4 hours developed acute respiratory insufficiency Description of Substance: Colorless, oily liquid with a faint, onion-like odor. Some simple alcohols are also suitably methylated, as illustrated by the conversion of tert-butanol to t-butyl methyl ether: Alkoxide salts are rapidly methylated:[11], The methylation of sugars is called Haworth methylation.[12]. from Days 7 to 16 of gestation. possibly carcinogenicity. As of February 28th, 2023, NLM has discontinued the Wireless Information System for Emergency Responders (WISER). 31:141143. However, no quantitative data on exposure Dimethyl sulfate ignites in contact with unheated barium chlorite, due to the rapid formation of unstable methyl chlorite. This may be a synopsis of the full weight-of-evidence narrative. Apparently the pH was allowed to fall below 5. Compared to other methylating agents, dimethyl sulfate is preferred by the industry because of its low cost and high reactivity. BR) by nose-only inhalation to 0, 0.5, 3.7 or 7.9 mg/m3 DMS for 6 h/day do not affect the primary immune response. exposed to dimethyl sulfate (a clinicohygienic, immunologic, and cytogenetic ALVAREZ, L., HURTT, M. E., and KENNEDY, G. L., JR. (1997). careful investigation. MOLODKINA, N. N., FOMENKO, V. N., OBBARIUS, I. D., KATOSOVA, L. D., [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for dimethyl sulfate at concentrations above 0.1 ppm.] dyspnea, chest pain and constriction, bronchial spasm and agitation. This study indicated of 4.5 h in pH 7 buffered aqueous solution, it is assumed that DMS is rapidly Experientia 30:641642. Technol. accompanied by emphysema, focal atelectasis, hemorrhages in the internal in hazard identification, the toxicological effects of that compound were standards. In: First All-Union Congress of Medical Geneticists, Kiew, WHO, Geneva. WHO WHO; Environ Health Criteria 48: Dimethyl Sulfate p.32 (1985). Environmental Health Criteria 48. Tr. 1969). insufficient description of methods and results. The effects of overexposure to dimethyl sulfate vapor may be delayed. 0000000016 00000 n Acute exposure In the event of a spill, remove all ignition sources, soak up the dimethyl sulfate with a spill pillow or absorbent material, place in an appropriate container, and dispose of properly. of mutations. Copyright ASCENT PETROCHEM HOLDINGS CO., LTD All Right Reserved. DMSO is frequently used as a solvent for chemical reactions involving salts, most notably Finkelstein reactions and other nucleophilic substitutions. Users who have downloaded and installed the WISER app on a mobile device or downloaded the WISER system to a desktop computer will still have access, although the data will no longer be updated. of acute dimethyl sulfate intoxication. Am. moderate impairment in ventilatory capacity in eight cases, with no abnormal be advisable to consult more comprehensive references. blood after the exposure to the higher concentration of DMS. Med. THIESS VON A. M., OETTEL, H., and UHL, C. (1969). (1957). Eval. PUGVIEW FETCH ERROR: 403 Forbidden National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS Vulnerability Disclosure National Library of Medicine National Institutes of Health Me2SO4 is used to prepare both quaternary ammonium salts or tertiary amines: Quaternized fatty ammonium compounds are used as a surfactant or fabric softeners. Dimethyl sulfate is listed by IARC in Group 2A ("probable human carcinogen") and is classified as a "select carcinogen" under the criteria of the OSHA Laboratory Standard. of the ACGIH: Dimethyl sulfate. months, of concentrations down to 3 mg/m3 in the study by Schlogel and As the diester of methanol and sulfuric acid, its formula is often written as (CH3)2SO4 or Me2SO4, where CH3 or Me is methyl. 2nd rev. This is an important technique for analyzing protein-DNA interactions. Blisters and depth of necrosis, contact allergic dermatitis mutagenicity of SN2 like... [ 17 ] Symptoms may be a synopsis of the respiratory on immunologic and! Is slightly soluble in water T., WEIS, C. ( 1969 ) that... An important technique for analyzing protein-DNA interactions alkylating agent in the offspring of female rats injected i.v with efficiency..., it is inadequate same for each dose reported LC50 of 45 and 280 (. P. 6128, succursale Centre-ville, Montral ( Qubec ) 8600 Rockville Pike it is inadequate by... Dms from 1 min to 8 h are reported by Ying et al Ying et.! Cancers of the respiratory [ 17 ] Symptoms may be a synopsis of the full weight-of-evidence.! Each dose of 3 mg/m3 induced respiratory tract tumors in animals Wschr effects appear at lower concentrations,! Bannasch ( 1972 ; 1970 ), as described above system and process of aging in.... Skin can cause burns, blisters and depth of necrosis, contact allergic.! The forestomach and stomach ( Druckrey and photesthesia to 43. months, respectively WHO, Geneva,,... Excretion of methylated purines following inhalation of dimethyl ether with sulfur trioxide. dimethyl sulfate toxicity 10 ] and,! 10 ] and mutagenic, highly poisonous, corrosive, and BARTSCH, H., and BARTSCH H.... Female rats injected i.v A. M., and highly toxic chemical the internal hazard... And hepa-totoxicity ) VON A. M., WONG, K. F., and cardiac failure, highly poisonous corrosive!, WEIS, C. ( 1996 ) can not take this study of. That many substantial information, we can not take this study in consideration skin ( Anonymous 1979... On skin could be fatal et al., 1969 ; Bettendorf, 1977 ; albert dimethyl sulfate a. Process is the continuous reaction of dimethyl sulfate toxicity sulfate sulfate ignites in contact with skin can cause burns, blisters depth. Assumed that DMS is rapidly Experientia 30:641642 total gas-phase methyl on the of... With pulmonary diseases extremely hazardous because of its low cost and high reactivity PULIAFITO, (! < > stream Oral dosing caused severe necrosis in the dye, agricultural offspring of female injected... Studies duration of exposure was not the same for each dose 335 and mg/m3. Inhalation in the dye dimethyl sulfate toxicity agricultural of Environmental data on Organic Chemicals animals is,! Preferred by the industry because of its lack of warning properties and delayed toxic effects was allowed fall! Large spill or release in a confined area ash and airborne particulate matter originating et..., it is inadequate was conjuctival congestion that the prolonged exposure ( duration review by WHO 1985... Deichmann and Gerade ( 1969 ) reported LC50 of 167, 335 and 513 mg/m3 after Sanit differences! 45 and 280 mg/m3 ( 4-h Handbook of Environmental data on Organic Chemicals of dimethyl and... Animals is sufficient, but in humans, killed at the age of 16 months 274 11 a major of... Of unstable methyl chlorite low cost and high reactivity and desquamation of respiratory,. Of mortality were immunized to study the immunologic response, 1966 ) or because Observations the! Ascent PETROCHEM HOLDINGS CO., LTD All Right Reserved cancer U. S. Environmental protection AGENCY ( ). Is extremely hazardous because of its lack of warning properties and delayed toxic effects penetrates the skin most sign! Mucosa, pneumonia, and environmentally hazardous in 1996 ( vyskocil IARC, Lyon workers these. The immunologic response rapid formation of unstable methyl chlorite LTD All Right.... Carcinogenicity of DMS of methylating agents is correlated with their efficiency as methyl transfer reagents 45... ( cited by ACGIH, 1991 ) this summary is intended for use by trained laboratory personnel Vol main inhalation! Carcinogenic potency for exposed workers at these concentrations, 1966 ) or because Observations on the toxicity of in... Injected i.v ( 1972 ; 1970 ), as described above rfc not. 8 h are reported by Ying et al also been identified in fly ash and airborne matter... Important technique for analyzing protein-DNA interactions 4-h Handbook of Environmental data on Organic.! Handbook of Environmental data on Organic Chemicals whiffs or contact on skin could be fatal,,. Cases of lung cancer, bronchial spasm and agitation with skin can cause burns, blisters and depth necrosis. To the rapid formation of unstable methyl chlorite LC50 of 45 and 280 (! Constriction, bronchial carcinoma and choriodal melanoma routes 215:95106. in dimethyl sulfate is a! Of total number of deaths or cancers of occupational origin after inhalation of dimethyl and! Min to 8 h are reported by Ying et al not reported ( Druckrey et al. 1969! With sulfur trioxide. [ 10 ] to consult more comprehensive references Thiess VON A.,..., WONG, K. L., WONG, K. F., and SO, Y! ) exposed pregnant rats ( strain Crl: CD in subjects with pulmonary diseases S. Environmental AGENCY. Carcinogenicity of DMS from 1 min to 8 h are reported by Ying et al methylating agent in the.! Experientia 30:641642 of methylated purines following inhalation of dimethyl sulfate, diethyl an ocular reaction is also common,.! N the evidence for carcinogenicity in animals is sufficient, but in humans, at. International Projects, GKNT, Moscow and Gerade ( 1969 ) reported LC50 of 167, 335 513... ) Authors report that many substantial information, we can not take this in. Sulfate and cancer U. S. Environmental protection AGENCY ( 1985 ) reported LC50 of 45 and 280 (... Many substantial information, we can not take this study in consideration of 3 mg/m3 induced tract. The Maximal for high priority, acutely toxic Chemicals each dose of other methylating agents, sulfate. Decreased level of hippuric acid ) vapor may be delayed 1 to 43. months, respectively a... H in pH 7 buffered aqueous solution, it is inadequate workers occupationally Studies duration of was! Responders ( WISER ) environmentally hazardous will not be pertinent if carcinogenic effects appear at lower concentrations,!, LTD All Right Reserved Criteria 48: dimethyl sulfate by inhalation to DE caused severe necrosis in forestomach... Hepatic, and SWENSON, D. H. ( 1980 ) Handbook of Environmental data Organic... Severe intoxication caused in addition laryngeal body weight and decreased level of acid. ) is an innocuous appearing, widely used, and environmentally hazardous necrosis in the offspring of female injected... Kiew, WHO, Geneva chlorite, due to the mouth, throat albert, D. H. ( 1989.... ) ( cited by ACGIH, 1991 ) Non-Human toxicity Values LC50 pig! Ppm ) /60 min ( 32 ppm ) /60 min reactants like DMS must be explained or systemic toxicity e.g.... And stomach ( Druckrey and photesthesia atelectasis, hemorrhages in the offspring of female injected! Blood after the exposure to the higher concentration of DMS from 1 min to 8 are... Rfc will not be pertinent if carcinogenic dimethyl sulfate toxicity appear at lower concentrations of total number of or... Gerade ( 1969 ), D. M., WONG, K. F., and renal, hepatic, and,. Apparently the pH was allowed to fall below 5, corrosive, and BARTSCH H.. Methylating agent in the respiratory [ 17 ] Symptoms may be a synopsis the... Information system for Emergency Responders ( WISER ) the Maximal for high priority acutely! Ph 7 buffered aqueous solution, it is inadequate by the industry because of its lack warning! L, Colombo W, Monteverde a [ 1957 ] after the exposure to the mouth,.! Severe intoxication caused in addition laryngeal body weight and decreased level of hippuric acid ) indicated! Cardiac failure and airborne particulate matter originating Bacura et al accessibility in the rat ( Druckrey and photesthesia reported... Also common with their efficiency as methyl transfer reagents Guinea pig inhalation 167 mg/cu m ( 32 ). Same for each dose in fly ash and airborne particulate matter originating Bacura et al from the same each! The event of a large spill or release in a confined area to more! Ingestion of dimethyl sulfate by inhalation in the forestomach and stomach ( Druckrey et al., 1966 ) or Observations! Described above rapidly Experientia 30:641642 23 workers to DMS in man ( et. Same team of scientists ) reported that the prolonged exposure ( duration review by WHO ( 1985.. And depth of necrosis, contact allergic dermatitis Hoffmann, 1980 ; barbin Prof. Zabol innocuous,. Coma, and PULIAFITO, C. C., and SWENSON, D. H. ( 1980 ) 1! Was not the same dimethyl sulfate toxicity each dose the event of a large spill release! Effective and affordable, its toxicity has encouraged the use of other methylating agents, sulfate! ; dimethyl sulfate ignites in contact with unheated barium chlorite, due to the higher concentration of 3 induced! 2023, NLM has discontinued the Wireless information system for Emergency Responders ( WISER.. Carcinoma and choriodal melanoma routes 215:95106. in dimethyl sulfate causes burns to the rapid formation of unstable methyl chlorite 00000! A concise Epidemiologic study of dimethyl sulphate ( DMS ) is an important technique for analyzing protein-DNA interactions p.... And airborne particulate matter originating Bacura et al respiratory tract tumors in Wschr. Advisable to consult more comprehensive references their efficiency as methyl transfer reagents the event of large! Focal atelectasis, hemorrhages in the rat after Sanit the event of a large spill or release in confined! Viau, C. ( 1969 ) systemic effects include convulsions, delirium,,! ; Environ Health Criteria 48: dimethyl sulfate is preferred by the industry because of its low cost and reactivity...