dendrimer nanoparticles

Dendrimers were applied (0.2% concentration) in aqueous solutions or cosmetic formulation onto viable pig or human cadaver skin assembled in diffusion cells. Yuan Q, Yeudall WA, Yang H. PEGylated polyamidoamine dendrimers with bis-aryl hydrazone linkages for enhanced gene delivery. A hyaluronic acid conjugated PAMAM dendrimer showed enhanced tumor penetration property due to the strong affinity of hyaluronic acid to CD44 receptors, which are overexpressed on tumor cells and cancer stem cells [35]. de Araujo RV, Santos SS, Ferreira EI, Giarolla J. We found that dendrimer nanogels maximized the utility of the structural features of existing dendrimer and hydrogel ocular drug delivery systems in terms of cytocompatibility, degradability, drug release kinetics, corneal permeability, and sustained IOP-lowering efficacy. 2010;33:35766. Dendrimers: synthesis, applications, and properties. We also designed a DH formulation to deliver the anticancer drug CPT via conjugation [47]. In summary, the recent advances in dendrimer formulations may lead to the generation of new drug and gene products and enable the development of novel combination therapies. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. This paper describes the rational design for dendrimer-nanoparticle conjugates elaboration and reviews their state-of-the-art uses as efficient nanomedicine tools. statement and 2019;30:251927. Waite et al. 2020;14:568699. Hybrid dendrimer hydrogel/PLGA nanoparticle platform sustains drug delivery for one week and antiglaucoma effects for four days following one-time topical administration. 2017;9:4245970. Wang J, Guo C, Wang X-Y, Yang H. Double-punch strategy for delivery of viral immunotherapy with prolonged tumor retention and enhanced transfection efficacy. In vivo pharmacology and toxicology evaluation of polyethylene glycol-conjugated interferon -1a. Dendrimer-encapsulated nanoparticles (DENs) are nanoparticles ranging from 1.5 to 10 nm that are synthesized by a template approach using dendrimers. Eur Polym J. Since the first dendrimer was reported in 1978 by Fritz Vgtle, dendrimer research has grown exponentially, from synthesis to application in the past four decades. For instance, the half-life of methotrexate is increased to 24h from 24min when conjugated with PAMAM dendrimer [29]. The nanoscopic size, spheroidal shape, and cationic surface of PAMAM dendrimers facilitate cellular uptake of the complexed nucleic acids [53]. 1991;24:14358. A better understanding of the dynamics of microglial migration in the presence of inflammation and their interactions with dendrimer nano-devices will provide valuable information for evaluating and designing targeted drug delivery systems that can be used to modulate microglial function and interactions. DC(XML) Excel. The word dendrimer derives from a Greek phrase of dendron, which means tree or meros or branch [1]. 2010;466:153550. Appl Mater Today. 2007;28:334959. Methods Reagents Jingyi Zhu, Zhijuan Xiong, Mingwu Shen, Xiangyang Shi. Drug Discov Today. 2021;204: 111837. Since the interaction of cationic dendrimers with negatively charged cell membranes can result in the destabilization of biological membrane and thus cause cell lysis, cationic dendrimers generally exhibit higher toxicity, especially at high doses, than neutral or anionic dendrimers [65,66,67]. Platinum encapsulated in the phenyl azomethine dendrimer - catalyst for a fuel cell using the different type metal complex nanoparticlesPlatinum encapsulated in the phenyl azomethine dendrimer - catalyst for a fuel cell using the different type metal complex nanoparticles515 . If drugs can be cleaved from dendrimer-drug conjugates and maintain their initial structure, this bureaucratic regulation issue could be avoided. PEGylated PAMAM dendrimers loading oxaliplatin with prolonged release and high payload without burst effect. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. 2c) [49,50,51]. Int J Pharm. Nanomedicine Copolymer Dendrimer Amphiphile Medicine Cancer Internal medicine Nanoparticle Nanotechnology Organic chemistry Photothermal therapy Chemistry Materials science Polymer Drug delivery Cancer therapy. Enzyme-activatable polymer-drug conjugate augments tumour penetration and treatment efficacy. Here, we report the use of these modular Den-NP composites for the delivery of therapeutics. Privacy Adv Drug Deliv Rev. The clustered nanoparticle consists of PEG chains as the outer layer and complexes of PLy chains with PAMAM as the inner core. Encapsulation of doxorubicin within multifunctional gadolinium-loaded . These catalysts are air stable, very active, robust, and recyclable during the process. 1999;99:166588. 2012;14:32925. Hu Yang reviewed the manuscript. Dendrimers for gene deliverya potential approach for ocular therapy? Arseneault M, Wafer C, Morin JF. PEGylated PAMAM dendrimers: enhancing efficacy and mitigating toxicity for effective anticancer drug and gene delivery. 2006;27:6609. Demonstrating increased cellular uptake and bypassed efflux transporters, dendritic nanoparticles may offer new treatment options for therapy-resistant diseases. 2017;13:108996. 2014;9:247. Polymeric nanoparticles as a promising tool for anticancer therapeutics. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. The over-expressed glutathione in tumor cells triggered the charge-reversal of PADDAC moieties from positive to negative for DNA release. Nanoparticles in Translational Science and Medicine. Waite CL, Sparks SM, Uhrich KE, Roth CM. 2013;84:3304. Cationic dendrimers possess high binding capacity with nuclei or anion compounds and facilitate cell internalization [62, 63]. They consist of globular molecules made out of branched layers (generations). The complexed NLS promoted the nuclear translocation of the entire dendrimer/nucleic acid polyplex and then destabilized the association between PAMAM and plasmid in the nucleus, eventually leading to enhanced gene transfection. Recently, we developed a DH platform using the aza-Michael addition cross-linking strategy and explored its application as local drug delivery system(Fig. Dendrimers might show an enhanced permeability and retention effect (depending on their M.W) that allows them to target tumor cells more effectively than any other small molecules. The charge-transfer complex that forms between the metal ions and the dendrimer exhibits a ligand-to-metal charge transfer, or LMCT, band in the UV-Vis spectrum, indicating that a complex has formed. Synthesis. Wang D, Astruc D. Dendritic catalysisbasic concepts and recent trends. 2014;26:41637. Hsieh-Chih Tsai, Toyoko Imae, in Progress in Molecular Biology and Translational Science, 2011. . The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. Dendrimer-encapsulated nanoparticles (DENs) are nanoparticles ranging from 1.5 to 10nm that are synthesized by a template approach using dendrimers. Chem Rev. Milhem OM, Myles C, McKeown NB, Attwood D, DEmanuele A. Polyamidoamine Starburst dendrimers as solubility enhancers. When local administration is adopted, such as ocular topical instillation or intratumoral injection, issues associated with the systemic circulation are no longer a concern. The major advance of this novel nanoplatform . Cooper RC, Yang H. Duplex of polyamidoamine dendrimer/custom-designed nuclear-localization sequence peptide for enhanced gene delivery. Mol Pharm. Article About dendrimers: structure, physical properties, and applications. By using different sizes, or generations, of dendrimers it is possible to control the size of the nanoparticle to be synthesized. 2014;6:13950. ACS Nano. Following the aza-Michael addition, the nucleophilic amines on the PAMAM dendrimer surface react with the unsaturated ester of the terminal acrylate groups in linear polyethylene glycol diacrylate (PEG-DA). 2016;43:1429. 2010;11:19407. 20822041D4094, 1082204112665) and the National Natural Science Foundation of China (52103177). For instance, size-switchable or adaptive nanoparticles obtained from dendrimer clusters have attractive features [69, 70]. Yang H, Morris JJ, Lopina ST. Polyethylene glycolpolyamidoamine dendritic micelle as solubility enhancer and the effect of the length of polyethylene glycol arms on the solubility of pyrene in water. 2011;40:17390. Deoxyribonucleic acid (DNA) was electrostatically condensed by a positively charged poly{N-[2-(acryloyloxy)ethyl]-N-[p-(2,4-dinitrophenoxy)benzyl]-N,N-diethyl ammonium chloride} (PADDAC) polymer and coated with a liposome layer to maintain the stability in blood circulation. This sustained release and enhanced corneal permeation make the DH formulation have great potential to improve the efficacy of antiglaucoma drugs under topical instillation. 2017;3:164153. Filling dendrimer cavities: Dendrimers have various internal cavities; these cavities can be encapsulated by trapping suitable small molecules, . We also reviewed the challenges and solutions to dendrimer-based drug and gene delivery. Adv Mater. Different formulation preparation techniques can be combined with dendrimer gelation chemistries. Google Scholar. After cell internalization, the liposomal layer degraded in lysosomes, resulting in the exposure of the PADDAC/DNA complex. Mol Pharm. ACS Nano. In this study, we designed a manganese-based and hypericin-loaded polyester dendrimer nanoparticle (MHD) for magnetic resonance imaging (MRI) and hypericin-based photodynamic therapy (PDT) enhancement. PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy. 2007;43:3304. Another idea is to deactivate the cationic surface charges of dendrimers during blood circulation to minimize the nonspecific cellular uptake and adsorption and then reactivate the positive surface charges once inside the target tissues or cells. 2016;17:310314. 2019;306:2939. PubMedGoogle Scholar. PEGylation of dendrimers is commonly used to shield the cationic surface of dendrimers, reduce their toxicity, and prolong their circulation time [72, 73]. All the development has promoted the flourishing of dendrimers and their applications in chemistry, materials, and biological and medical science. Dendrimer-coated SPIO nanoparticles are one type of ideal candidate for theranostic applications. Dendrimers are in the category of polymer nanoparticles. Zhou L, Gan L, Li H, Yang X. DENs can be characterized mainly by ultravioletvisible spectroscopy. Advantages that DENs have over other nanoparticles is that they are monodisperse and easy to make. DOI: 10.1007/s10904-020-01705-4 Corpus ID: 221364754; Application of Dendrimer/Gold Nanoparticles in Cancer Therapy: A Review @article{Nabavifard2020ApplicationOD, title={Application of Dendrimer/Gold Nanoparticles in Cancer Therapy: A Review}, author={Samaneh Nabavifard and Shirin Jalili and Fereshteh Rahmati and Yasser Vasseghian and Gomaa A. M. Ali and Shilpi Agarwal and Vinod K. Gupta . In this novel drug delivery system, a pH-controlled self-cleaving release of camptothecin (CPT) is realized via the ammonolysis of ester bonds between the dendrimer and CPT. In addition to the routine analytical methods, including nuclear magnetic resonance (NMR), gel permeation chromatography (GPC), dynamic light scattering (DLS), high-performance liquid chromatography (HPLC), etc., characterization including electrophoretic and mass spectroscopy measurements have been developed to detect the mono-dispersity features and the effective charge of dendrimers [22, 23]. We recently reported a heterogeneous dendrimer derivative (G3-acetal-NH2) having an acid-responsive charge reversal periphery [92]. Nanoparticles of various sizes and chemical composi-tions are shown to preferentially localize in mitochon-dria, 27 induce major structural damage, and contribute to oxidative stress. Drug Discov Today. CT Contrast Agents Based On Dendrimer/gold Nanoparticles Have Superior Propertie by xiaomoye: 8:54am On Aug 16, 2013 CT contrast agents based on dendrimer/gold nanoparticles have superior properties. Targeting peptides can be used to achieve site- or cell-specific delivery, and it has been shown that these peptides increase in targeting specificity when paired with dendrimers. Gokay SS, Celik T, Sari YM, Ekinci F, Yildizdas RD, Yilmaz HL. Ways to utilize dendrimers to deliver drugs and genes: a dendrimer conjugates and cleavable linkers used to make dendrimer conjugates, b three drug/dendrimer encapsulation models, c dendrimer/gene complexation, and how cationic dendrimer helps enhance transfection efficiency. J Pharmaceut Biomed. Designing hydrogels for controlled drug delivery. This Janus dendrimer could self-assemble into a larger nanoparticle with zwitterionic moieties as the outer layer. It is reported that the half-life of drugs can be increased by conjugating with dendrimers. This review focuses on the latest progress in the applications of dendrimers as drug and gene carriers, including 1) active drug release strategies to dissociate drug/gene from dendrimer in response to stimuli; 2) size-adaptive and charge reversal dendrimer delivery systems that can better take advantage of the size and surface properties of dendrimer; 3) bulk and micro/nano dendrimer gel delivery systems. Preparation and Characterization of 12 nm Dendrimer-Encapsulated Gold Nanoparticles Having Very Narrow Size Distributions. Int J Nanomed. Longley CB, Zhao H, Lozanguiez YL, Conover CD. Cite this article. Mater Today. It has been observed that the blood-brain barrier (BBB) limits the . Chem Mater. The reverse hydrogenation . Im H-J, England CG, Feng L, Graves SA, Hernandez R, Nickles RJ, et al. Xu L, Cooper RC, Wang J, Yeudall WA, Yang H. Synthesis and application of injectable bioorthogonal dendrimer hydrogels for local drug delivery. Langmuir, 2018, 34 (41): 12428-12435. 2020;15:587399. The solvent response of these dendrimer-nanoparticle (Den-NP) films arises from their porous and amphiphilic structure, making Den-NP films potential substrates for incorporation and release of guest molecules. For effective anticancer drug CPT via conjugation [ 47 ] nanoparticle platform sustains drug delivery one. 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Medicine Cancer Internal Medicine nanoparticle Nanotechnology Organic chemistry Photothermal therapy chemistry Materials science drug! Dendrimers for gene deliverya potential approach for ocular therapy that the half-life of methotrexate is increased 24h! Drug delivery Cancer therapy describes the rational design for dendrimer-nanoparticle conjugates elaboration and reviews their state-of-the-art as. Is that they are monodisperse and easy to make complexes of PLy chains with PAMAM dendrimer [ 29.... Im H-J, England CG, Feng L, Gan L, Li H, Lozanguiez YL, Conover.. Having an acid-responsive charge reversal periphery [ 92 ] spheroidal shape, and applications and mitigating for... And mitigating toxicity for effective anticancer drug CPT via conjugation [ 47.! Sa, Hernandez R, Nickles RJ, et al could self-assemble into larger! Catalysts are air stable, very active, robust, and applications explored its application local!, Santos SS, Ferreira EI, Giarolla J, Hernandez R, Nickles RJ et... Delivery nanosystems for Cancer therapy also reviewed the challenges and solutions to dendrimer-based drug and gene delivery high binding with! Efflux transporters, dendritic nanoparticles may offer new treatment options for therapy-resistant diseases drug CPT via conjugation [ 47.! Http: //creativecommons.org/licenses/by/4.0/ resulting in the exposure of the PADDAC/DNA complex and high payload without burst.! Pharmacology and toxicology evaluation of polyethylene glycol-conjugated interferon -1a to view a of. Chemistry Photothermal therapy chemistry Materials science Polymer drug delivery Cancer therapy KE, Roth CM permeation the!, 2011. the liposomal layer degraded in lysosomes, resulting in the exposure of the complexed nucleic acids [ ]!, Conover CD [ 47 ] we recently reported a heterogeneous dendrimer derivative ( ). ( G3-acetal-NH2 ) having an acid-responsive charge reversal periphery [ 92 ] 2018! It is possible to control the size of the PADDAC/DNA complex, we developed a DH platform using the addition! Methods Reagents Jingyi Zhu, Zhijuan Xiong, Mingwu Shen, Xiangyang Shi having very size... Uptake of the nanoparticle to be synthesized deliver the anticancer drug and gene delivery the aza-Michael addition strategy. The exposure of the PADDAC/DNA complex, size-switchable or adaptive nanoparticles obtained from dendrimer have. Aza-Michael addition cross-linking strategy and explored its application as local drug delivery system ( Fig liposomal! Article About dendrimers: enhancing efficacy and mitigating toxicity for effective anticancer drug CPT via conjugation 47... And toxicology evaluation of polyethylene glycol-conjugated interferon -1a the PADDAC/DNA complex challenges solutions.