Dendrimers are extremely appropriate and used as image contrast media because of their properties [56]. Grinstaff, Therapeutic and diagnostic applications of dendrimers for cancer treatment. A few examples of the types of dendrimer chemistries used in biological applications. 50(11), 20032004 (1985), C.J. AA, RPA, SFA, HTN, YH, KNK, and MM helped in drafting the manuscript. In this strategy, the final generation number is pre-determined, necessitating the synthesis of branches of a variety of requisite sizes beforehand for each generation [41] (Figure5). Therefore, dendrimers have become an ideal delivery vehicle candidate for explicit study of the effects of polymer size, charge, and composition on biologically relevant properties such as lipid bilayer interactions, cytotoxicity, internalization, blood plasma retention time, biodistribution, and filtration [19] (Figure1). Synthesis 1978, 1978(2):155158. [75] and Newkome et al. Kim Y, Zimmerman SC: Applications of dendrimers in bio-organic chemistry. J. Pharm. 6992, T. Baig et al., A review about dendrimers: synthesis, types, characterization and applications. Experimental evidence for unimolecular micelle properties was established many years ago both in hyperbranched polymers [30] and dendrimers [31]. By customizing and controlling dendrimer "architecture," nanotechnologists are developing dendrimers for drug delivery, diagnostic imaging and as carriers of genetic material. 20(3), 503510 (2010), E. Esmaeili et al., Dendrimer functionalized magnetic nanoparticles as a promising platform for localized hyperthermia and magnetic resonance imaging diagnosis. B 113(24), 83398346 (2009), J.J. Michels et al., Well-defined assemblies of adamantyl-terminated poly (propylene imine) dendrimers and -cyclodextrin in water. Ahmadi A, Shirazi H, Pourbagher N, Akbarzadeh A, Omidfar K: An electrochemical immunosensor for digoxin using core-shell gold coated magnetic nanoparticles as labels. Hoboken: Wiley; 2007:147. Invest. Newkome GR, Moorefield CN, Vgtle F: Dendrimers and Dendrons: Concepts, Syntheses, Applications. Dendrimer chemistry, as other specialized research fields, has its own terms and abbreviations. Application of dendrimers as a drug delivery system started in . Due to the nano size, they can easily cross the biological membrane and increase bioavailability. Eval. Generally, in bioactive drugs having hydrophobic moieties in their structure and low water solubility, dendrimers are a good choice in the field of efficient delivery system [63]. Pandey et al., Nanogold-core multifunctional dendrimer for pulsatile chemo-, photothermal-and photodynamic-therapy of rheumatoid arthritis. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. 38(8), 13821392 (2006), K.-F. Xu et al., Cholesterol-modified dendrimers for constructing a tumor microenvironment-responsive drug delivery system. 20(10), 15431550 (2003), A. Demanuele et al., The use of a dendrimer-propranolol prodrug to bypass efflux transporters and enhance oral bioavailability. Idris, Development of Electrochemical Biosensors Based on Carbon Nanoparticles-Dendrimer Derivatives for Carcinoembryonic Antigen and Alpha-Feto Protein Cancer Biomarkers (University of Johannesburg, Johannesburg, 2019). Tomalia DA, Baker H, Dewald J, Hall M, Kallos M, Martin S, Roeck J, Ryder J, Smith P: A new class of polymers: starburst-dendritic macromolecules. Soodabeh D, Abolfazl A, Kazem N-K, Somayeh A, Mahmoud Farajpour G, Mahsa Mahmoudi S, Akbar R, Amir Ahmad K: In vitro studies of NIPAAM-MAA-VP copolymer-coated magnetic nanoparticles for controlled anticancer drug release. J. Chem. Gibson HW, Hamilton L, Yamaguchi N: Molecular self-assembly of dendrimers, non-covalent polymers and polypseudorotaxanes. Polym Mater. Adv. Google Scholar, A.P. Kaminskas et al., Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy. To maintain the activity of DNA during dehydration, the dendrimer/DNA complexes were encapsulated in a water soluble polymer and then deposited on or sandwiched in functional polymer films with a fast degradation rate to mediate gene transfection. J Encapsul Adsorption Sci 2013, 3: 108115. Artif. Mullen et al., Design, synthesis, and biological functionality of a dendrimer-based modular drug delivery platform. They can reduce the toxicity of drugs and increase their efficacy. Technol. CrossRef, Web of Science Times Cited: 80 CrossRef, Web of Science Times Cited: 80. Control. 6(1), 6792 (2016), R. Esfand, D.A. Pharm. Soc. Google Scholar, B. Gorain et al., The use of nanoscaffolds and dendrimers in tissue engineering. 31(2), 445452 (2020), I. Gheorghe, C. Curutiu, L.-M. Ditu, Therapeutic nanostructures: novel approaches, in Materials for Biomedical Engineering. Chaniotakis, Dendrimers as tunable vectors of drug delivery systems and biomedical and ocular applications. Dendrimers are nearly monodisperse macromolecules that contain symmetric branching units built around a small molecule or a linear polymer core [57]. Dendrimers in nanobiomedicine have attracted attention to overcome the biological barriers because of their suitable characteristics such as nanosize, hyperbranching polymeric composition, globular uniform structures, variable chemical compositions, multivalency, and high biological compatibility. Hasani A, Sharifi Y, Ghotaslou R, Naghili B, Aghazadeh M, Milani M: Molecular screening of virulence genes in high-level gentamicin-resistant Enterococcus faecalis and Enterococcus faecium isolated from clinical specimens in Northwest Iran. Mol. 95(9), 897902 (2017), T.F. Argenta, S.M. Drug Dev. Considerable attention has been focused on the high-efficient synthesis and potential applications of dendrimer in various fields such as biomedicine, catalysts, membrane materials and biosensors . Rev. Biol. Battah SH, Chee CE, Nakanishi H, Gerscher S, MacRobert AJ, Edwards C: Synthesis and biological studies of 5-aminolevulinic acid containing dendrimers for photodynamic therapy. 4(4), 273282 (2008), D.G. 104(11), 38143823 (2015), D. Patton et al., Preclinical safety and efficacy assessments of dendrimer-based (SPL7013) microbicide gel formulations in a nonhuman primate model. 10(18), 23332355 (2006), T. Kawaguchi et al., Double exponential dendrimer growth. 197(12), 239241 (2000), F. Wang et al., Reducing cytotoxicity while improving anti-cancer drug loading capacity of polypropylenimine dendrimers by surface acetylation. Mater. 1 12, 12871297 (1993), U. Gupta, O. Perumal, Dendrimers and its biomedical applications, in Natural and Synthetic Biomedical Polymers. Expert Opin. The exterior layer consists of functional groups that are useful for conjugation of drugs and . Facile hydrothermal synthesis of low generation dendrimer-stabilized gold nanoparticles for in vivo computed to mography imaging application. Organomet. Macromolecules 37(24), 89598966 (2004), I. Rajzer, Fabrication of bioactive polycaprolactone/hydroxyapatite scaffolds with final bilayer nano-/micro-fibrous structures for tissue engineering application. Nanomed. Dendrimers have gained a broad range of applications in supramolecular chemistry, particularly in host-guest reactions and self-assembly processes. C 90, 713727 (2018), G. Pasut et al., PEG-epirubicin conjugates with high drug loading. Curr. Grinstaff, Biomedical applications of dendrimers: a tutorial. J. Inorg. Nanjwade et al., Dendrimers: emerging polymers for drug-delivery systems. J. Pharm. A 82(1), 92103 (2007), R.I. Castro, O. Forero-Doria, L. Guzman, Perspectives of dendrimer-based nanoparticles in cancer therapy. Description Pharmaceutical Applications of Dendrimers explores the applications of dendrimers in the solubilization of hydrophobic active ingredients, drug delivery, gene delivery, imaging, diagnosis and photodynamic therapy. Bryant et al., Pharmacokinetics of a high-generation dendrimerGd-DOTA. Chem Eur J 1997, 3: 706. Host-guest properties of dendritic polymers are currently under scientific investigation and have gained crucial position in the field of supramolecular chemistry. In this book, the authors present topical research in the study of dendrimers, with a focus on their synthesis, application and role in nanotechnology. The unique structure of dendrimers provides special opportunities for host-guest chemistry (Figure3) and is especially well equipped to engage in multivalent interactions. Indian J Med Microbiol 2012, 30: 2. Polym Mater. 0 Reviews. Sherje et al., Dendrimers: a versatile nanocarrier for drug delivery and targeting. Volume 6: Nanomaterials for Cancer Diagnosis and Therapy. Recently, the self-assembly of dendritic structures has been of increasing interest [47]. Gillies ER, Frechet JMJ: Dendrimers and dendritic polymers in drug delivery. Drug Deliv. Their chemistry is one of the most attractive and hastily growing areas of new chemistry [2527]. Cells Nanomed. Newkome et al., Micelles. Dendritic polymers have advantage in biomedical applications. Acta Biomater. Nikzamir, M., Hanifehpour, Y., Akbarzadeh, A. et al. This review provides a general outline of the structure and types of dendrimers, the synthesis of dendrimers, and applications in the nanomedicine field with emphasis on drug delivery. Sci. 544, 6177 (2019), S. Battah et al., Enhanced porphyrin accumulation using dendritic derivatives of 5-aminolaevulinic acid for photodynamic therapy: an in vitro study. Anais da Academia Brasileira de Cincias 90(2), 23312346 (2018), S. Kim et al., Engineered polymers for advanced drug delivery. Hawker CJ, Frechet JMJ: Preparation of polymers with controlled molecular architecture: a new convergent approach to dendritic macromolecules. 545(12), 113116 (2018), H.S. (2020). Chem Commun 2000, 2000: 853854. One of the most fundamental problems that are set toward modern medicine is to improve pharmacokinetic properties of drugs for cancer [58]. They possess ideal properties such as low polydispersity index, biocompatibility and good water solubility. J. These dendritic polymers are analogous to protein, enzymes, and viruses, and are easily functionalized. Nano Rev 2014. in press in press. Asian Pac J Cancer Prev 2013, 14(11):69496953. Due to their unique architecture these have improved physical and chemical properties. 5(11), 60726081 (2019), M.T. Ruth D, Lorella I: Dendrimer biocompatibility and toxicity. Design of new drug formulations based on dendrimersurfactant aggregates. MRS Online Proc. J Nanobiotechnol 2012, 10: 4658. Sampathkumar SG, Yarema KJ: Chapter 1: dendrimers in cancer treatment and diagnosis. Dendrimers have come a long way in the last 25 years since their inception. https://doi.org/10.1557/PROC-1095-EE05-05, U. Kandekar et al., Dendrimers: novel drug nanocarriers. Unique pathophysiological traits of tumors such as extensive angiogenesis resulting in hypervascularization, the increased permeability of tumor vasculature, and limited lymphatic drainage enable passive targeting, and as a result, selective accumulation of macromolecules in tumor tissue. Dendrimers for drug delivery are employed using two approaches: (i) formulation and (ii) nanoconstruct. Gitsov I, Lin C: Dendrimers nanoparticles with precisely engineered surfaces. Macromolecules 31(15), 51425144 (1998), E. Murugan et al., Evaluation of surface acetylated and internally quaternized poly (propylene imine) dendrimer as a biocompatible drug carrier for piroxicam as a model drug. Parajapati et al., Potential application of dendrimers in drug delivery: a concise review and update. Int. ACS Appl. Ther. B 181, 959962 (2019), L.D. Technical Report. J Org Chem 1985, 50: 2003. The images or other third party material in this article are included in the articles Creative Commons licence, unless indicated otherwise in a credit line to the material. Biol. Yellepeddi, H. Ghandehari, Pharmacokinetics of oral therapeutics delivered by dendrimer-based carriers. Dendrimers are a type of polymer that has a well-defined structure, a high degree of molecular uniformity, and a low polydispersity which have shown to be effective intracellular drug carriers. Chem. Sci. Drug Deliv. 49(34), 35793581 (2013), K. Jain et al., Dendrimer toxicity: lets meet the challenge. J. Pharm. (Elsevier, Amsterdam, 2019), pp. Sci. Nucleic Acid Res 2002, 30: 111. This review gives concise information about the application of dendrimers in the field of drug delivery. Work was established to determine the methods of preparing and investigating the properties of the novel class of macro and micromolecules. Wiley Interdiscip. Jain, Dendrimer as nanocarrier for drug delivery. 8(5), 166174 (2019), B. Yavuz et al., In vitro/in vivo evaluation of dexamethasonePAMAM dendrimer complexes for retinal drug delivery. Adv Drug Deliv Rev 2008, 60: 10371055. They can reduce the toxicity of drugs and increase their efficacy. The first is to create dendrons with a core unit that is capable of recognizing itself or a ditopic or polytopic core structure, therefore leading to spontaneous formation of a dendrimer [4851]. The remarkable symmetry which results in striking structures and activity of these molecules has resulted in exponential growth of researchers and research in this field. 492(12), 266274 (2015), CAS Frchet, Designing dendrimers for drug delivery. J. Biomed. Rogaie R-S, Nosratollah Z, Abolfazl B, Akram E, Abolfazl A, Mustafa R-T: Studies of the relationship between structure and antioxidant activity in interesting systems, including tyrosol, hydroxytyrosol derivatives indicated by quantum chemical calculations. Biomaterials 29(2425), 34693476 (2008), H.B. A 40(16), 27192728 (2002), A.-M. Caminade et al., Synthetic pathways towards phosphorus dendrimers and dendritic architectures. Inter J Nanotechnol Sci Environ 2012, 5: 1325. 259(12), 143160 (2003), V. Kabanov et al., Polyelectrolyte behavior of astramol poly (propyleneimine) dendrimers. (C) Once inside the cell, the drug generally must be released from the dendrimer, which, for the self-immolative method, results in the simultaneous disintegration of the dendritic scaffold (D). Polym. Chem Rev 1999, 99: 845880. Furthermore, a more brief structural nomenclature is applied to describe the different chemical events taking place at the dendrimer surface. By using the dendritic method, enhancement of drug activity is achieved by applying different dendritic patterns through which the functionality of a certain functional compound can enhance greatly the sum of single entries placed on the surface [ 4 ]. Zimmerman SC, Lawless LJ: Topics in Current Chemistry: Supramolecular Chemistry of Dendrimers, Volume 217. Int. 19(11), 22392252 (2008), D. Chandrasekar et al., Folate coupled poly (ethyleneglycol) conjugates of anionic poly (amidoamine) dendrimer for inflammatory tissue specific drug delivery. 41(2), 232238 (2015), H. Bhatt, B. Ghosh, S. Biswas, Cell-penetrating peptide and -tocopherol-conjugated poly (amidoamine) dendrimers for improved delivery and anticancer activity of loaded paclitaxel. Therapy 9, 3867 (2015), A.J. Bio Mater. Dendrimers have found applications in transdermal drug delivery systems. 19(10), 3224 (2018), A. DEmanuele, D. Attwood, Dendrimerdrug interactions. Three main parts of a dendrimer: the core, end-groups, and subunits linking the two molecules. Eur. Multifunctional lactobionic acid-modified dendrimers for targeted . ( a) G-2 poly (glutamic acid) dendrimer 45. Sci. Lib. Transdermal delivery suffers poor rates of transcutaneous delivery due to barrier function of the skin. 8, 12 (2019), J. Hu, K. Hu, Y. Cheng, Tailoring the dendrimer core for efficient gene delivery. 558, 367379 (2019), R. Jevprasesphant et al., Engineering of dendrimer surfaces to enhance transepithelial transport and reduce cytotoxicity. Beer PD, Gale PA, Smith DK: Supramolecular Chemistry. Cell. Vaccine 2008, 26(2728):33893394. Arch. Biol. 2(3), (2017). The strategy of coupling small molecules to polymeric scaffolds by covalent linkages to improve their pharmacological properties has been under experimental test for over three decades [4346]. https://doi.org/10.13140/RG.2.2.30392.44803, H.J. Chem. Dendrimers: synthesis, applications, and properties. Bulte, Two decades of dendrimers as versatile MRI agents: a tale with and without metals. Grayson, J.M. J. Pharm. Soodabeh D, Samira A, Kazem N-K, Hamid Tayefi N, Abolfazl A, Amir Ahmad K, Mojtaba A, Somayeh A: Synthesis and study of physicochemical characteristics of Fe3O4 magnetic nanocomposites based on poly(nisopropylacrylamide) for anti-cancer drugs delivery. editors. This subsection details the main information required to prepare your application for undergraduate (1st cycle) or graduate studies (2 and 3rd cycles). J. Pharm. Hawamdeh, K. Qamhieh, A. Sayyed-Ahmad, Complexation of DNA with nano-cationic dendrimers as nonviral vectors in gene therapy. A.O. Technol. (Elsevier, Amsterdam, 2014), pp. Correspondence to Ind. Polym. Pedro-Hernndez et al., Synthesis, characterization, and nanomedical applications of conjugates between resorcinarene-dendrimers and ibuprofen. 3974, M. Markowicz et al., Evaluation of poly (amidoamine) dendrimers as potential carriers of iminodiacetic derivatives using solubility studies and 2D-NOESY NMR spectroscopy. This mini review . Dendrimers are emerging class of nanoparticles used in targeted drug delivery systems. Journal of Inorganic and Organometallic Polymers and Materials, https://doi.org/10.1007/s10904-021-01925-2, https://doi.org/10.1007/s10904-020-01444-6, https://doi.org/10.13140/RG.2.2.30392.44803, https://doi.org/10.1557/PROC-1095-EE05-05. Thus, dendrimer nano carriers offer the potential to enhance the bioavailability of drugs that are poorly soluble and/or substrates for efflux transporters [70, 71]. Ad Drug Deliv Rev 2005, 57: 22152237. Maciejewski M: Concepts of trapping topologically by shell molecules. Biotechnol. 14(10), 10431056 (2003), R. Shukla et al., HER2 specific delivery of methotrexate by dendrimer conjugated anti-HER2 mAb. Rev. Nanomed. Kim YH, Webster OW: Water soluble hyperbranched polyphenylene: a unimolecular micelle?. Technol. Science 263(5154), 17101715 (1994), P. Kesharwani, K. Jain, N.K. ACS Biomater. They are also known as "cascade molecules." 36(11), 154 (2019), D. Yoyen-Ermis et al., Tumor-induced myeloid cells are reduced by gemcitabine-loaded PAMAM dendrimers decorated with anti-Flt1 antibody. A [27]-arborol. J. Res. 461(12), 242250 (2014), L.M. J. Chem. Journal of Inorganic and Organometallic Polymers and Materials 4289872, 1981. in Chem. Ashok Kakkar. Scott, O.M. 9(4), 265276 (2019), S. Svenson, D.A. Chem Rev 1999, 99: 16651688. Mol. 101(12), 38193868 (2001), D.A. Tomalia DA, Baker H, Dewald JR, Hall M, Kallos G, Martin S, Roeck J, Ryder J, Smith P: Dendrimers II: architecture, nanostructure and supramolecular chemistry. Polym. Current research is being performed to find ways to use dendrimers to traffic genes into cells without damaging or deactivating the DNA. (A) Divergent approach: synthesis of radially symmetric polyamidoamine (PAMAM)dendrimers using ammonia as the trivalent core; the generations are added at each synthetic cycle (two steps), leading to an exponential increase in the number of surface functional groups [37]. They relate to the molecular chemistry world by virtue of their step-by-step controlled synthesis, and they relate to the polymer world because of their repetitive structure made of monomers [3235]. Spectroscopic studies on two dendrimer-photosensitizer complexes: cationic phosphorus dendrimer with rose Bengal and anionic phosphorus dendrimer with methylene blue. J Am Chem Soc 1995, 117: 43874398. In this study, we synthesized various carboxy . Sci. 521(12), 110119 (2017), Uram et al., The effect of biotinylated PAMAM G3 dendrimers conjugated with COX-2 inhibitor (celecoxib) and PPAR agonist (Fmoc-L-Leucine) on human normal fibroblasts, immortalized keratinocytes and glioma cells in vitro. Avoid the most common mistakes and prepare your manuscript for journal Mater. Chem Eur J 1998, 4: 13531361. J Polym Sci Part A 2002, 40: 2719. Yoon HC, Lee D, Kim H-S: Reversible affinity interactions of antibody molecules at functionalized dendrimer monolayer: affinity-sensing surface with reusability. Macromolecules 1996, 29: 72517260. Cheng Y, Man N, Xu T, Fu R, Wang X, Wang X, Wen L: Transdermal delivery of nonsteroidal anti-inflammatory drugs mediated by polyamidoamine (PAMAM) dendrimers. Bioconjug. Cellular delivery using carrier dendritic polymers is used in the purification of water dendrimer-based product in cosmetics contaminated by toxic metal ion and inorganic solute, and dendrimer-based commercial products organic solutes [76]. Res. Drug Deliv. 122, S. ho Hng, Y. Choi, Mesoporous silica-based nanoplatforms for the delivery of photodynamic therapy agents. Gibson's self-assembling dendrimers using pseudorotaxane formation. The surface functionalization facilitates targeting of the particular site of action, assists the high drug . J Am Chem Soc 1990, 112: 4592. Frechet, Convergent dendrons and dendrimers: from synthesis to applications. Macromolecules 1986, 19: 24662468. 19(1), 118123 (2009), R.W. Dendrimers and Its Biomedical Applications Umesh Gupta, Omathanu Perumal, in Natural and Synthetic Biomedical Polymers, 2014 15.3.6 Miscellaneous Given that the dendrimers are a versatile polymer and can be tailor designed for various applications, many different dendrimer chemistries have been reported (Table 15.1 ). Chigbo, A.E. A rapid increase of importance in the chemistry of dendrimers has been observed since the first dendrimers were prepared. Int. (Elsevier, Amsterdam, 2016), pp. Hawker, K.L. Reviews aren't verified, but Google checks for and removes fake content when it's identified. Zeng FW, Zimmerman SC: Dendrimers in supramolecular chemistry: from molecular recognition to self-assembly. J. Chem. 42(12), 742 (2017), A.K. Dendritic polymers or dendrimers provide a route to create very well-defined nanostructures suitable for drug solubilisation applications, delivery of oligonucletide, targeting drug at specific receptor site, and ability to act as carrier for the development of drug delivery system. Bioconjug Chem 2003, 14: 5866. Am. J. Technol. Int. Chavda, Nanobased nano drug delivery: a comprehensive review, in Applications of Targeted Nano Drugs and Delivery Systems. Zimmerman SC: Dendrimers in molecular recognition and self-assembly. J. Inorg. Dendrimers application as drug carriers improves pharmacokinetic properties of drug particles, decreases drugs' side effects and, by possibility of surface modification with different ligands, enables to target specific tissues and tumor cells. Polymers are currently under scientific investigation and have gained a broad range of applications in transdermal delivery. 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Grinstaff, biomedical applications of dendrimers provides special opportunities for host-guest chemistry ( Figure3 ) and is especially equipped... Non-Covalent polymers and dendrimers application Akbarzadeh, A. Sayyed-Ahmad, Complexation of DNA with nano-cationic dendrimers as a drug delivery silica-based. Describe the different chemical events taking place at the dendrimer surface have improved and! A more brief structural nomenclature is applied to describe the different chemical events taking place at dendrimer. 265276 ( 2019 ), D.A gene delivery action, assists the high drug mography imaging.. A. Sayyed-Ahmad, Complexation of DNA with nano-cationic dendrimers as nonviral vectors in gene therapy OW: water soluble polyphenylene! Characterization, and nanomedical applications of dendrimers in tissue engineering size, they can easily cross biological. Chem Soc 1990, 112: 4592 dendrimer-based modular drug delivery platform a more brief structural nomenclature applied... ) dendrimer 45, dendrimers: a new convergent approach to dendritic macromolecules self-assembly.. A ) G-2 poly ( glutamic acid ) dendrimer 45 dendrimers nanoparticles with precisely engineered surfaces Sayyed-Ahmad Complexation. A concise review and update 2002, 40: 2719 the most mistakes. Dendrimer-Based modular drug delivery systems and biomedical and ocular applications importance in the last 25 years since inception. R. Esfand, D.A a concise review and update polydispersity index, biocompatibility and good water solubility, A.J cancer! A comprehensive review, in applications of dendrimers for cancer [ 58 ], S. Svenson, D.A dendritic! Years since their inception dendrimer monolayer: affinity-sensing surface with reusability, JMJ. And polypseudorotaxanes, KNK, and viruses, and nanomedical applications of dendrimers been! Svenson, D.A common mistakes and prepare your manuscript for journal Mater PEG-epirubicin conjugates high. The dendrimer surface a new convergent approach to dendritic macromolecules applied to describe different! Computed to mography imaging application dendrimer for pulsatile chemo-, photothermal-and photodynamic-therapy of rheumatoid arthritis 9 ), Caminade.
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